Doctor Doom, Doctor Strange, and Molecule Man confront the Beyonders in a last-ditch attempt to prevent the end of the Multiverse, as the final Incursion of Earth-1610 and Earth-616 begins. Heroes from each universe confront one another. Both Mister Fantastic and Maker (the Mister Fantastic of Earth-1610) realize the situation is futile and make plans to survive the cataclysm with a small group of colleagues; Mister Fantastic selects heroes and important scientists, while Maker intends to preserve himself and the Cabal. Maker sends a doomsday weapon and the Children of Tomorrow to Earth-616. During the battle, Black Bolt, Rocket Raccoon, Groot, Black Widow, Spider-Woman, and Beast are killed and Stark Tower is destroyed. But a temporary, amalgamation of worlds, "Battleworld" is created.
Mister Fantastic and Doctor Doom face off, a short time later, leading to the destruction of Battleworld, however, In the wake of the destruction, Black Panther uses the Reality Gem to recreate, and teleport himself to, Wakanda. There, he finds three Wakandan prodigies who he tasks with granting wisdom to the stars, and they manage to restore Earth-616.
But the Multiverse is far from restored. As a result of the Incursions and the destruction of Battleworld, orphaned residents of other universes are appearing here, on Earth-616. Black Panther, along with Doctor Doom, Scarlet Witch, Doctor Strange and Mister Fantastic are hard at work trying to fix reality and re-create the other universes, but until then, Earth-616 has become the home away from home for many.